Researchers identify enzyme an increased risk of colon inflammation in obese people

Researchers identify enzyme an increased risk of colon inflammation in obese people

Researchers from University of Massachusetts Amherst have identified an enzyme, called soluble epoxide hydrolase (sEH), “that might be responsible for increased colon inflammation in obese people.” As such, researchers hope that by inhibiting the enzyme they may be able to prevent colon cancer. Several drugmakers “are already in the process of developing sEH inhibitors for human trials for other conditions.” The findings were published in PNAS.

Hopefully this becomes a simple thing to measure and can make a dent in one of the “additional” risks of morbid obesity. It would be nice if they can tell us why some people have it and some do not, or whether the bacterial content of the colon is involved.
What we know now is limited: If you are obese, you are probably at a higher risk than if you were not.
If you are male and obese, you are at higher risk, especially over age 50.
It makes sense for anyone who is obese to follow the screening guidelines for first colonoscopy at age 50 or 10 years earlier than any blood relative who was diagnosed with cancer.
It also makes sense to consider bariatric surgery which will reduce ALL of your risks.
Bariatric surgery has the likelihood of adding 7-10 years to your lifespan.

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The NJBI Team